A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/319.3
A61K 8/90 (2006.01) A61K 8/43 (2006.01) A61K 8/73 (2006.01) A61Q 11/00 (2006.01)
Patent
CA 2000464
The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavour which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.
a difficulté de concevoir un dentifrice compatible aven un agent antibactérien bis-biguanide, par exemple la chlorhexidine ou l'alexidine, est résolue en utilisant un agent épaississant non ionique, un surfactant non ionique et un abrasif, qui est soit un sel peu soluble, par exemple le carbonate de calcium (utilisé de concert avec un agent inhibant la formation d'anions), un composé essentiellement insoluble, par exemple une silice à faible contenu anionique, ou un agencement des deux. La composition a, de préférence, essentiellement un goût d'anis équilibré par la menthe. Lorsque l'on prépare un dentifrice contenant de la silice, il vaut mieux ajouter la chlorhexidine et la saccharine ensemble dans les premières étapes du processus afin d'éviter la formation de grumeaux. Ces dentifrices sont utiles dans la prophylaxie ou le traitement des parodontopathies et des caries.
Alexander Stephen E.
Doel Geoffrey R.
Edwards Peter J.
Beecham Group P.l.c.
Borden Ladner Gervais Llp
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