Deoxyfluoronucleoside process

Details Deoxyfluoronucleoside process Deoxyfluoronucleoside process

C - Chemistry, Metallurgy

07

H

260/210, 260/229

C07H 19/09 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2029301

Abstract Of the Disclosure There is disclosed a process for synthesizing 2'- fluoro-2',3'-dideoxyarabinofuranose derivatives of inosine and adenine on a large scale which involves coupling of a fluorosugar derivative and a purine reactant to provide a purine nucleoside intermediate which is then deoxygenated. 6-Chloro or 6-benzamidopurine and 1,3,5-tri-0-benzoyl-2- deoxy-2-fluoroarabinofuranose are used as starting materials.

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