C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/445 (2006.01)
Patent
CA 2551060
The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
L'invention concerne une nouvelle classe d'analogues de la désoxynojirimycine, ou de sels pharmaceutiquement acceptables de ceux-ci, ces composés pouvant être utilisés de façon appropriée pour traiter une maladie parmi l'insulinorésistance, la maladie de Gaucher, des maladies inflammatoires, des états d'hyperpigmentation et/ou d'inflammation cutanée, la surcharge pondérale et l'obésité, des troubles du stockage lysosomal, des mycoses, des mélanomes et d'autres tumeurs, ainsi que des infections microbactériennes. L'invention concerne en outre une composition pharmaceutique comprenant ledit analogue de la désoxynojirimycine, ou un sel pharmaceutiquement acceptable de celui-ci, ainsi qu'un support pharmaceutiquement acceptable.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Genzyme Corporation
Macrozyme B.v.
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