C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/445 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) C07J 43/00 (2006.01)
Patent
CA 2260790
Deoxynojirimycin derivatives containing a large hydrophobic moiety, such as cholesterol or adamantame-methanol, linked through a spacer, such as pentamethylene, to the nitrogen atom of deoxynojirimycin, and salts thereof, inhibit glucosylceramidase and may be useful in the treatment of diseases involving a ceramide-mediated signalling process, such as Gaucher disease.
Des dérivés de désoxynojirimycine contenant une fraction hydrophobe importante, telle que cholestérol ou adamantene-méthanol, liée par l'intermédiaire d'un espaceur, tel que du pentalméthylène, à l'aide d'azote de déoxynojirimycine, ainsi que des sels de ceux-ci, sont des inhibiteurs de désoxynojirimycine qui peuvent être utiles dans le traitement de maladies impliquant un processus de signalisation à médiation céramide, par exemple la maladie de Gaucher.
Aerts Johannes Maria Franciscus Gerardus
Koomen Gerrit Jan
Overkleeft Herman Steven
Pandit Upendra Kumar
Vianello Paola
Borden Ladner Gervais Llp
Genzyme Corporation
Universiteit Van Amsterdam
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