C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
195/1.23, 195/1.
C12Q 1/68 (2006.01)
Patent
CA 1240629
ABSTRACT OF THE DISCLOSURE A single-stranded deoxyribonucleic acid molecule having a length of less than about 25 kb comprises at least three distinct nucleotide sequences which are the sites for incorporation into a chromosome of a deoxyribonucleic acid molecule encoding a deleterious gene. Deoxyribonucleic acid probes have been prepared from such molecules and are useful as hybridization probes for detecting chromosomal deoxyribo- nucleic acid which has a deoxyribonucleic acid molecule encoding a deleterious gene incorporated therein. A single-stranded deoxyribonucleic acid molecule derived from human chromosome 22 which is about 5.8 kb in length contains sites for incorporation of a deoxyribonu- cleic acid molecule encoding the oncogene c-ab1 derived from human chromosome 9. Deoxyribonucleic acid probes have been prepared from this molecule and used to detect the abnormal Philadelphia chromosome and chronic myelocytic leukemia.
471634
Groffen Johannes H.
Heisterkamp Eleonora C.
Stephenson John R.
Gowling Lafleur Henderson Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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