Deoxyribonucleoside phosphoramidites in which an aliphatic...

Details Deoxyribonucleoside phosphoramidites in which an aliphatic... Deoxyribonucleoside phosphoramidites in which an aliphatic...

C - Chemistry, Metallurgy

07

H

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C07H 19/06 (2006.01) C07H 19/067 (2006.01) C07H 19/073 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01) C07H 19/173 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 1311428

ABSTRACT OF THE DISCLOSURE The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile, permitting amino groups to be selectively placed at any position on oligonuc- leotides of any composition or length which is attain- able by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

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