Depigmenting activity of agouti signal protein and peptides...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C12Q 1/26 (2006.01) C12Q 1/533 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2224691

The invention is an agouti signaling protein and peptides as well as pharmaceutical compositions thereof and their use in methods of inhibiting melanin production by melanocytes. The agouti signaling protein and peptides thereof are useful in cosmetics and in clinical prevention and treatment of hyperpigmentary conditions. Methods for screening peptides for melanogenesis inhibiting activity are also provided.

L'invention se rapporte à une protéine-signal d'agouti et à ses peptides, ainsi qu'à leurs compositions pharmaceutiques et à leur utilisation dans des procédés d'inhibition de la production de mélanine par des mélanocytes. La protéine-signal d'agouti et ses peptides sont utilisés dans des produits cosmétiques et, dans des applications cliniques pour la prévention et le traitement de l'hyperpigmentation. L'invention se rapporte également à des procédés de criblage de peptides pour déterminer leur activité d'inhibition de la mélanogénèse.

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