Depot-steroid esters

Details Depot-steroid esters Depot-steroid esters

C - Chemistry, Metallurgy

07

J

260/7

C07J 7/00 (2006.01) C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 11/00 (2006.01) C07J 21/00 (2006.01) C07J 31/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1086305

ABSTRACT OF THE DISCLOSURE Steroid esters having depot action in which the 17-position is substituted by i) an alkynyl radical in the .alpha.-position or an acetyl radical in the R-position, and by ii) a group of the general formula -O-CO-Z in which Z represents X-OH, Y-CO-OH, X-O-CO-Y-CO-OH, X-O-CO-R, Y-CO-OR, X-O-CO-Y-CO-OR, or X-O-SO2-R, in which X represents a saturated hydrocarbon radical having from 1 to 6 carbon atoms which may be uninterrupted or interrupted by one or more of the same or different atoms selected from oxygen and sulphur, and may be unsubstituted or substituted by one or more of the same or different substituents selected from -OH, -OCOR and -OSO2R groups, Y represents a direct bond, an aliphatic radical which may be uninterrupted or interrupted by one or more of the same or different atoms selected from oxygen and sulphur, and which has from 1 to 3 carbon atoms in the case where Y is bound through -O-CO- to the steroid residue, or from 1 to 16 carbon atoms in the case where Y is bound through -O-CO- to X, or a cyclohexylene, cyclopentylene or phenylene group which may be unsubstituted or substituted by one or more of the same or different substituents selected from methyl and ethyl groups, and, R represents a hydrocarbon radical having from 1 to 22 carbon atoms

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