Depression of herg k+ channel function in mammalian cells...

Details Depression of herg k+ channel function in mammalian cells... Depression of herg k+ channel function in mammalian cells...

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/18 (2006.01) A61K 31/4468 (2006.01) A61K 31/4545 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2597341

The use of an HERG channel inhibitor for controlling the proliferation of cancer cells. Examples of such HERG channel inhibitors include dofetilide, cisapride, E-4031 and a siRNA molecule targeting a sequence involved in the expression of an HERG channel. Other ERG channels are also targets for these inhibitors.

L'invention concerne l'utilisation d'un inhibiteur de canal HERG pour réguler la prolifération de cellules cancéreuses. Des exemples de ces inhibiteurs de canal HERG comprennent le dofétilide, le cisapride, E-4031 et une molécule de siRNA ciblant une séquence impliquée dans l'expression d'un canal HERG. D'autres canaux HERG sont également des cibles pour ces inhibiteurs.

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