Deprotection and recrystallization processes

C - Chemistry – Metallurgy – 07 – D

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C07D 471/02 (2006.01) C07D 223/12 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2317718

Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite. Such agents are also employed in the recrystallization and reprocessing of the mercaptoalkanoylamino lactam acids.

Des esters ou des acides d'acylmercaptoalkanoylamino lactam sont transformés en ester ou acide de mercaptoalkanoylamino lactam correspondant dans des conditions basiques par l'inclusion d'un agent qui réduit la quantité de disulfures. Les agents appropriés sont les bismercaptans, les agents réducteurs de phosphine ou phosphite, de la poudre de métal de zinc et de l'hydrosulfite de sodium. Des agents de ce type sont également utilisés dans la recristallisation et le retraitement des acides de mercaptoalkanoylamino lactam

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