Depsipeptides and their therapeutic use

Details Depsipeptides and their therapeutic use Depsipeptides and their therapeutic use

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/06 (2006.01) A61K 38/15 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07K 11/00 (2006.01)

Patent

CA 2670372

Compounds which are Spiruchostatin analogues of the general formula (I) or (I'), isosteres thereof and pharmaceutically acceptable salts thereof are found to inhibit HDAC wherein R1, R2, R3 and R4 are the same or different and represent an amino acid side chain moiety and each R6 is the same or different and represents hydrogen or C1-C4 alkyl.

Des composés qui sont des analogues de Spiruchostatine de la formule générale (I) ou (I'), des isostères de ceux-ci et des sels pharmaceutiquement acceptables de ceux-ci inhibent HADC où R1, R2, R3 et R4 sont identiques ou différents et représentent une fraction de chaîne latérale d'acide aminé et chaque R6 est identique ou différent et représente chacun un hydrogène ou un alkyle en C1-C4.

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