C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2321277
A method of derivatising antibodies to expose carbohydrate chains so that the antibodies are capable of binding to immobilised IgG, such as agalactosyl IgG, is disclosed. The derivatised antibodies are useful in the diagnosis and treatment of conditions associated with immobilised IgG, such as rheumatoid arthritis (RA), in a preferred embodiment providing a non-invasive technique which can detect the immobilised IgG in situ, thereby assisting in the diagnosis or treatment of conditions associated with it, such as autoimmune disorders including rheumatoid arthritis, juvenile arthritis, Crohn's disease, type I insulin dependent diabetes, type II diabetes, sarcoidosis, erythema nodosum leprosum and tuberculosis, and especially in the diagnosis of erosive joint disease.
L'invention concerne une technique qui permet de dérivatiser des anticorps de façon à exposer les chaînes de glucides, ce qui permet aux anticorps de se fixer sur des IgG immobilisées, telles que l'IgG agaloctosylique. Ces anticorps dérivatisés sont utiles pour le diagnostic et le traitement des états associés à l'immobilisation d'IgG, tels que la polyarthrite rhumatoïde (RA). Dans un mode de réalisation préféré, la technique est une technique non invasive qui permet de détecter les IgG immobilisées in situ, ce qui facilite le diagnostic ou le traitement des états associés à la présence desdites IgG, tels que les troubles immunitaires (notamment polyarthrite rhumatoïde, polyarthrite chronique juvénile, maladie de Crohn, diabète insulino-dépendant de type I, diabète de type II, sarcoïdose, érythème noueux lépreux et tuberculose), en particulier le diagnostic de la forme érosive de la polyarthrite rhumatoïde.
Rademacher Thomas William
Williams Phillip
Bereskin & Parr
University College London
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