Derivative of tissue-type plasminogen activator

Details Derivative of tissue-type plasminogen activator Derivative of tissue-type plasminogen activator

C - Chemistry, Metallurgy

12

N

530/13, 195/39.1

C12N 15/58 (2006.01) A61K 38/49 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) C12N 15/30 (2006.01)

Patent

CA 2017636

A new tissue-type plasminogen activator (t-PA)-derivative is not glycosylated and has the following amino acid sequence: (M) Ser Tyr Gln Val Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly 10 ~~ 15 Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys 20 25 30 Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg 35 ~~ 40 ~~ 45 Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg 50 ~~ 55 ~~ 60 Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly 65 70 75 80 Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn 85 90 95 Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser 100 105 110 Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu 115 120 125 Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly 130 135 140 Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro 145 ~~ 150~~~155~~ 160 Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp 165 170 175 Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln 180 ~~185 ~~ 190 Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp 195 ~~ 200 ~~205 Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe 210 ~~215~~ 220 Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala 225 ~~ 230 235 ~~ 240 His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu 245 250 255 Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu 260 265 270 Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp 275 280 ~~285 Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala 290 ~~295 ~~ 300 Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu 305 ~~ 310 ~~315 320 Gln Leu Pro Asg Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His 325 ~~ 330 ~~335 Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val 340 ~~345 ~~ 350 Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg 355 ~~ 360 ~~365 Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly 370 ~~375 ~~ 380 Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 385 ~~ 390 ~~395 ~~ 400 Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly IIe Ile Ser 405 ~~ 410 ~~415 Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys 420 ~~425 ~~ 430 Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 435 ~~ 440 ~~445 and is suitable for dissolving blood clots.

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