Derivative of tissue-type plasminogen activator

Details Derivative of tissue-type plasminogen activator Derivative of tissue-type plasminogen activator

C - Chemistry, Metallurgy

12

N

195/39.1, 195/1.

C12N 15/58 (2006.01) A61K 38/49 (2006.01) C07K 1/113 (2006.01) C12N 9/68 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2025900

A new tissue-type plasminogen activator (t-PA)-derivative is not glycosylated and consists of the following amino acid sequence: Image It is coded by the following DNA-sequence Image and possesses particularly favourable properties when used to dissolve blood clots.

Nouveau dérivé d'activateur du plasminogène tissulaire (t-PA) qui n'est pas glycosilé et consiste en la séquence d'amino-acides (M) représentée par (I). Ce dérivé est encodé par la séquence d'ADN représentée par (II), et présente des propriétés thrombolytiques particulièrement intéressantes.

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