Derivatives and analogs of chroman as functionally selective...

Details Derivatives and analogs of chroman as functionally selective... Derivatives and analogs of chroman as functionally selective...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/353 (2006.01) A61P 25/06 (2006.01) C07D 405/08 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 417/14 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2678069

In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as .alpha.2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the .alpha.2C adrenergic receptors using such compounds or pharmaceutical compositions.

L'invention concerne, dans ses nombreux modes de réalisation, une nouvelle classe de composés chromane de formule (I) en tant qu'agonistes des récepteurs adrénergiques .alpha.2C, des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés, ainsi que des méthodes pour le traitement, la prévention, l'inhibition ou l'amélioration d'une ou plusieurs pathologies associées aux récepteurs adrénergiques .alpha.2C à l'aide de ces composés ou compositions pharmaceutiques.

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