Derivatives of 1,2,3,3a,8,8a-hexadydropyrrolo ¬2,3-b| indole

Details Derivatives of 1,2,3,3a,8,8a-hexadydropyrrolo ¬2,3-b| indole Derivatives of 1,2,3,3a,8,8a-hexadydropyrrolo ¬2,3-b| indole

A - Human Necessities

61

K

167/240

A61K 31/40 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1125657

ABSTRACT OF THE DISCLOSURE New derivatives of 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole having the formula Image wherein: Rl is selected from the group consisting of hydrogen, hydroxy, Cl-C12 alkoxy and C2-C12 alkenyloxy; R2 is selected from the group consisting of hydrogen and Cl-C12 alkyl; R3 and R4 are the same or different and are selected from the group consisting of hydrogen, Cl-C12 alkyl and C2-C12 alkenyl, provided that (a) when Rl is selected from the group consisting of hydrogen, hydroxy, methoxy and ethoxy, and R2 is methyl, at least one of R3 and R4 is other than hydrogen or methyl, and that (b) when Rl is hydroxy, R2 is methyl and R3 is hydrogen, R4 is other than methyl and the salts of these compounds with pharm- aceutically acceptable acids are described. Depending on the starting material, these compounds can be prepared by various methods. The compounds have an analgesic activity and so can be used as active substances in pharmaceutical compositions when combined with a suitable carriel.

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