Derivatives of 1,2,5-thiadiazole-1-oxide and 1,1- dioxides...

C - Chemistry – Metallurgy – 07 – D

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260/308.3

C07D 285/10 (2006.01)

Patent

CA 1248962

ABSTRACT Novel intermediates useful in the processes of making histamine H2-antagonists of the formula Image I wherein p is 1 or 2; R1 is hydroxy, amino, substituted amino or a 5- to 7-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; are disclosed. Also disclosed are processes for their preparation.

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