Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide,...

Details Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide,... Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide,...

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/416 (2006.01) A61K 31/551 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2549954

The invention relates to compounds having general formula (I), wherein X represents N or a group having formula C-R¿2?; P, Q, R and W each represent N or a group having formula C-R¿3?; R¿1? represents H or an alkyl; R¿2? represents an alkyl; R¿3? represents H or a halogen, or an alkyl, alkoxy, nitro, amino, trifluoromethyl, cyano group, or having general formula -NR¿4?R¿5?, -NR¿4?C ( =O ) R¿5?, -NR¿4?C ( =O ) NR¿5?R¿6?, - NR¿4?C ( =O ) OR¿5?, -NR¿4?S ( = ) ¿2?NR¿5?R¿6?, -OR¿4?, -OC ( =O ) R¿4,? -OC ( =O ) OR¿4?, -OC ( =O ) ONR¿4?R¿5,? -OC ( =O ) SR¿4?, -C ( =O ) OR¿4,? -C ( =O ) R¿4?, -C ( =O ) NR¿4?R¿5?, -SR¿4,? -S ( =O )R¿4?, -S ( =O ) ¿2?R¿4?, -S ( =O ) ¿2?NR¿4?R¿5?, or a heterocycle; and R¿4?, R¿5?, and R¿6? each represent H or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, or heterocycloalkyl or aryl. The invention also relates to the use of same in therapeutics.

Composés répondant répondant à la formule générale (I) dans laquelle X représente N ou un groupe de formule C-R2, P, Q, R et W représentent chacun N ou un groupe de formule C-R3, R1 représente H ou un alkyle, R2 représente un alkyle, R3 représente H ou un halogène, ou un groupe alkyle, alcoxy, nitro, amino, trifluorométhyle, cyano, ou de formule générale -NR4R5, -NR4C ( =O ) R5, -NR4C ( =O ) NR5R6, - NR4C ( =O ) OR5, -NR4S ( = ) 2NR5R6, -OR4, -OC ( =O ) R4, -OC ( =O ) OR4, -OC ( =O ) ONR4R5, -OC ( =O ) SR4, -C ( =O ) OR4, -C ( =O ) R4, -C ( =O ) NR4R5, -SR4, -S ( =O )R4, -S ( =O ) 2R4, -S ( =O ) 2NR4R5, ou un hétérocycle, R4, R5, et R6 représentent chacun H ou un alkyle, alcényle, alcynyle, cycloalkyle, cycloalkylalkyle, cycloalcényle, ou hétérocycloalkyle ou aryle. Application en thérapeutique.

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