Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol

Details Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol

C - Chemistry, Metallurgy

07

D

260/323, 260/298

C07D 207/12 (2006.01) C07D 317/28 (2006.01) C07D 407/04 (2006.01) C07D 491/056 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2028048

Novel derivatives of 1,4-dideoxy-1,4- imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6- trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-mannitol, have useful mannosidase inhibitory activity.

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