Derivatives of 10,11,12,13-tetrahydrodesmycosin processes...

Details Derivatives of 10,11,12,13-tetrahydrodesmycosin processes... Derivatives of 10,11,12,13-tetrahydrodesmycosin processes...

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) C07H 23/00 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2056823

The invention relates to derivatives of 10,11,12,13-tetrahydro-desmycosin, Image wherein R stands for O or (OC2H5)2, R1 stands for Si(CH3)3 or H, R2 stands for H, OH, I or OSO2CH3, which are novel semisynthetic antibiotics of the tylosin series, possessing antibacterial activity, to their pharmaceutically acceptable salts with inorganic or organic acids, to processes for their preparation and to their use in pharmaceutical preparations.

L'invention porte sur des dérivés de 10,11,12,13-tétrahydrodesmycosine Image - où R représente O ou (OC2H5)2, R1 est Si(CH3)3 ou H, R2 est H, OH, I ou OSO2CH3 -, qui sont de nouveaux antibiotiques semisynthétiques de la série de la tylosine, possédant une activité antibactérienne; ainsi que sur leurs sels pharmacocompatibles avec des acides minéraux ou organiques, et sur leur préparation et utilisation dans des compositions pharmaceutiques.

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