Derivatives of...

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C - Chemistry, Metallurgy

07

D

167/209, 260/237

C07D 417/12 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1281718

Abstract . Novel condensed seven-membered ring compouds of the formula: Image [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 and R5 are independently hydrogen, lower alkyl or aralkyl; R4 is hydrogen or lower alkyl; R6 is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoploxy.

471650

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