C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 15/10 (2006.01)
Patent
CA 2485872
The invention relates to novel chemical compounds of formula (I), which stimulate soluble guanylate cyclase, to the production and use thereof as medicament, particularly in the treatment of cardiovascular diseases and/or sexual dysfunction (I), wherein R1" represents chlorine, cyano, trifluoromethyl or methoxy and R2 represents hydrogen or fluorine or R1 represents fluorine and R2 represents fluorine. The invention also relates to the salts, isomers and hydrates of said compounds.
La présente invention concerne de nouveaux composés chimiques de formule (I) qui stimulent la guanylate cyclase soluble. L'invention a également pour objet leur préparation et leur utilisation comme produits pharmaceutiques, notamment comme produits pharmaceutiques pour traiter les maladies du système cardio-vasculaire et/ou les dysfonctionnement sexuels. Dans la formule (I): R?1¿ est chlore, cyano, trifluorméthyle ou méthoxy et R?2¿ est hydrogène ou fluor; ou R?1 ¿ est fluor et R?2¿ est fluor. L'invention concerne aussi des sels, des isomères et des hydrates de ces composés.
Bischoff Erwin
Muenter Klaus
Stahl Elke
Stasch Johannes-Peter
Weigand Stefan
Bayer Healthcare Ag
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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