Derivatives of 12, 13-epoxy-tylosin and processes of...

C - Chemistry – Metallurgy – 07 – H

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C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2183049

The invention relates to derivatives of 12,13-epoxy-tylosin, the novel semisynthetic antibiotics from the tylosin group and the methods for their preparation. According to this invention hydrogenation followed by oximation of 12,13-epoxy-tylosin derivatives yieldsthe following tylosin derivatives: 10,11-dihydro-12,13-epoxy, respectively 10,11-dihydro- 12,13-epoxy oxime. Direct oximation of 12,13-epoxy tylosin derivative gives 12,13-epoxy oxime derivatives of tylosin.

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