Derivatives of...

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C - Chemistry, Metallurgy

07

C

C07C 59/88 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/535 (2006.01) C07C 69/738 (2006.01) C07C 211/35 (2006.01) C07C 229/26 (2006.01) C07C 235/78 (2006.01) C07C 235/80 (2006.01) C07D 295/182 (2006.01)

Patent

CA 2044837

ABSTRACT The invention relates to 4-(2,4-difluorobi- phenylyl)-2-methyl-4-oxobutanoic acid derivatives having the general formula: Image (I) wherein X represents a morpholinyl radical or a group of the formula OR, NHR or (CH2)nNR'2 in which R is an alkyl radical of 1 to 4 carbon atoms, R' is a methyl or ethyl radical and n is 2 or 3, and to the pharmaceutically acceptable base addition salts of 4-(2,4-difluorobiphenyl- yl)-2-methyl-4-oxobutanoic acid, having the general formula: Image (II) wherein B? is an alkaline metal cation, an alkaline earth metal cation, a cyclohexylamine cation or a lysine cation. The compounds of formulas (I) and (II) are particularly useful for the treatment of inflammatory conditions.

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