Derivatives of...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/06 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2542370

The invention relates to compounds having general formula (I), wherein: R¿1? represents H or an alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl group; R¿2? represents a pyridinyl, furanyl, thienyl, thiazolyl or oxazolyl group, said group being optionally substituted; and R¿3? represents H, one or more substituents selected from among the halogen atoms and the trifluoromethyl, alkyl, cycloalkyl, alkoxy, phenyl, cyano, acetyl, benzoyl, thioalkyl, alkylsulfonyl, carboxy or alcoxycarbonyl groups, or a group having general formula NR¿4?R¿5? or SO¿2?NR¿4?R¿5? or CONR¿4?R¿5? in which R¿4? and R¿5? each represent H or an alkyl group or, together with the nitrogen atom bearing same, form a pyrrolidine, piperidine or morpholine ring, said compound taking the form of a base, an acid addition salt, a hydrate or a solvate. The invention also relates to the use of the compound in therapeutics.

Composés de formule générale (I) dans laquelle R1 représente H ou un groupe alkyle, cycloalkyle, cycloalkylalkyle, phénylalkyle, alcényle, alcynyle ; R2 représente un groupe pyridinyle, furanyle, thiényle, thiazolyle ou oxazolyle, ce groupe étant éventuellement substitué ; R3 représente soit H, soit un ou plusieurs substituants choisis parmi les atomes d'halogène et les groupes trifluorométhyle, alkyle, cycloalkyle, alcoxy, phényle, cyano, acétyle, benzoyle, thioalkyle, alkylsulfonyle, carboxy ou alcoxycarbonyle, ou un groupe de formule générale NR4R5 ou SO2NR4R5 ou CONR4R5 dans lesquelles R4 et R5 représentent chacun H ou un groupe alkyle, ou forment, avec l'atome d'azote qui les porte, un cycle pyrrolidine, pipéridine ou morpholine; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat. Application en thérapeutique.

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