Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o...

Details Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o... Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o...

C - Chemistry, Metallurgy

07

F

C07F 9/645 (2006.01)

Patent

CA 2521313

Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspartate (NMDA) receptor antagonists and are useful in treating a variety of conditions present in a mammal that benefit from inhibiting the NMDA receptor.

L'invention concerne des composés représentés par la formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule, R2 et/ou R3 ne représente pas hydrogène. Ces composés constituent des antagonistes du récepteur N-méthyl-D-aspartate (NMDA) et permettent de traiter chez un mammifère diverses affections pour lesquelles une inhibition du récepteur NMDA est bénéfique.

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