Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their...

Details Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their... Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their...

C - Chemistry, Metallurgy

07

D

C07D 319/06 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2044699

- 36 - ABSTRACT DERIVATIVES OF 2-AMINOALKYL-5-ARYLALKYL 1,3-DIOXANES THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION A compound which is a 2-aminoalkyl-5-arylalkyl 1,3- dioxane of general formula (I) Image (I) in which m represents 0 or 1; n represents 1, 2, 3 or 4: R1 represents hydrogen or methyl: R2 represents hydrogen, methyl or an alkanoyl group of the general formula COR' in which R' represents a hydrogen atom or a linear or branched Cl-C4-alkyl group, or an alkoxycarbonyl group of the general formula COOR" in which R" represents a linear or branched C1-C4-alkyl group; and Ar represents either a phenyl group optionally carrying one or two substituents selected from halogen, C1-C4 alkyl, methoxy and trifluoromethyl, or a naphthalen-l-yl or naphthalen-2-yl group optionally carrying a substituent selected from halogen, methyl, methoxy and cyclopropyl- methoxy groups, - 37 - in the form of a cis- or trans-stereoisomer, or in the form of a free base or an acid addition salt thereof and its therapeutic use.

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