Derivatives of 2-hydroxythiopene and -furan fused with a...

Details Derivatives of 2-hydroxythiopene and -furan fused with a... Derivatives of 2-hydroxythiopene and -furan fused with a...

C - Chemistry, Metallurgy

07

D

167/208, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2026386

Derivatives of 2-hydroxythiophene and -furan fused with a nitrogen-containing ring, process for preparing these and their application in therapy ABSTRACT The invention relate to compounds of formula Image I in which R1 is selected from the groups R3 and OR3, R is selected from H and a group CHR2R', in which R2 is selec- ted from H, alkyl, carboxy and carboxamido and R' is H, alkyl or phenyl, Z represents S or O; and m and n, which may be identical or different, equal 1 or 2, and their N-oxides, salts and quaternary ammonium derivatives. The invention also relates to the process for preparing these compounds, as well as to pharmaceutical compositions containing them. Fig. None

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