C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/381 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) C07D 209/02 (2006.01) C07D 209/12 (2006.01) C07D 209/52 (2006.01) C07D 213/46 (2006.01) C07D 213/81 (2006.01) C07D 333/16 (2006.01) C07D 333/38 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 451/02 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2755526
The invention relates to compounds of general formula (I) wherein R is a hydrogen atom or a group selected from the groups (C1-C6) aIkyI, (C3-C7) cycloalkyl, benzyl or allyl optionally substituted by at least one group selected independently from each other from the halogen atoms, the groups (C3-C7) cycloalkyl, (C1-C6) alkyl, (C1-C6) BlCOXy, hydroxy; R1 is a phenyl or naphtyl group, optionally substituted by at least one substitutent selected independently from each other from the halogen atoms, the groups (CrC6) alkyl, (C1-C6) BlCOXy, halo-(C1-C6) alkyl, hydroxy, halo-(C1C6) alcoxy, (C1-C6) alkyl-thio, (C1-C6)alkyl-SO, (C1C6) alkyl-SO2; Het is a heteroaryl group; and R2 is at least one substituent selected from the hydrogen atom, the halogen atoms, the groups halo-(d-C6) alkyl, (C1C6) alkyl, (C3-C7) cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3) alkyl, (C1- C6) alcoxy, benzyl, (C1C6) alkyl-thio, (C1C6) alkyl-SO, (C1C6) alkyl-SO2; in the base state or as addition salts for acids. The invention also relates to the use of said compounds in therapeutics and synthesis methods.
Les composés de l'invention répondent à la formule générale (I) dans laquelle R représente un atome d'hydrogène ou un groupe choisi parmi les groupes (C1-C6)aIkVIe, (C3-C7)-cycloalkyle, benzyle ou allyle éventuellement substitué par un ou plusieurs groupes choisis indépendamment l'un de l'autre parmi les atomes d'halogène, les groupes (C3-C7)-cycloalkyle, (C1-C6)alkyle, (C1- C6)B1COXy, hydroxy; R1 représente un groupe phényle ou naphtyle, éventuellement substitué par un ou plusieurs substituants choisis indépendamment l'un de l'autre parmi les atomes d'halogène, les groupes (CrC6)alkyle, (C1-C6)B1COXy, halo-(C1- C6)alkyle, hydroxy, halo -(C1C6)alcoxy, (C1-C6)alkyle-thio, (C1-C6)alkyle-SO, (C1C6)alkyle-SO2; Het représente un groupe hétéroaryle; R2 représente un ou plusieurs substituants choisis parmi l'atome d'hydrogène, les atomes d'halogène, les groupes halo- (d- C6)alkyle, (C1C6)alkyle, (C3-C7)cycloalkyle, (C3-C7)-cycloalkyl-(C1- C3)alkyle, (C1-C6)alcoxy, benzyl, (C1C6)alkyle-thio, (C1C6)alkyle-SO, (C1C6)alkyle-SO2; à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique et procédé de synthèse.
Estenne-Bouhtou Genevieve
Mafroud Abdel-Kader
Robic
Sanofi
LandOfFree
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