Derivatives of 4'-demethyl-4-epipodophyllotoxin

C - Chemistry – Metallurgy – 07 – H

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260/230.58

C07H 17/04 (2006.01)

Patent

CA 1216287

ABSTRACT OF THE DISCLOSURE This invention relates to novel 4'-demethyl-4- epipodophyllotoxin derivatives represented by the general formula (I), and salts thereof: Image (I) wherein R is a lower alkyl group, and X1 and X2 are independently a hydroxyl group or an amino group, the one being an amino group and the other being a hydroxyl group. These novel derivatives have a high carcinostatic activity and a relatively high water solubility and hence are expected to be useful as carcinostatics.

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