Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)...

Details Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)... Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 17/12 (2006.01) A61P 17/14 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2478701

Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

L'invention concerne des composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et p sont tels que définis dans la description, des sels pharmaceutiquement acceptables et des esters hydrolysables in vivo. L'invention concerne également des procédés de préparation de ces composés et leur utilisation en tant que médicaments, en particulier des médicaments conçus pour produire un effet inhibiteur de cycle cellulaire (anti-prolifération cellulaire) chez un homéotherme, tel qu'un être humain.

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