Derivatives of 4-(n-azacycloalkyl) anilides as potassium...

Details Derivatives of 4-(n-azacycloalkyl) anilides as potassium... Derivatives of 4-(n-azacycloalkyl) anilides as potassium...

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/472 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2661462

This invention provides a compound of formula (IA) where X = O or S; Y is O or S; q = 1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

La présente invention concerne un composé de formule IA: dans laquelle X = O ou S; Y est O ou S; q = 1 ou 0; et les autres substituants sont tels que definis dans la description. De tels composés peuvent affecter l'ouverture, ou moduler autrement, des canaux potassiques sensibles au voltage. Ils sont potentiellement utiles pour le traitement et la prévention de maladies et de troubles qui sont affectés par l'activation ou la modulation de canaux ioniques au potassium. Une telle condition est constituée par des troubles de crise.

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