Derivatives of 4-phenyl-1,4-dihydropyridine-3,...

Details Derivatives of 4-phenyl-1,4-dihydropyridine-3,... Derivatives of 4-phenyl-1,4-dihydropyridine-3,...

C - Chemistry, Metallurgy

07

D

167/229, 260/294

C07D 211/90 (2006.01) A61K 31/455 (2006.01)

Patent

CA 1268180

DERIVATIVES OF 4-PHENYL-1,4-DI-HYDROPYRIDINE-3 5-DICARBOXYLIC ACID ABSTRACT OF THE DISCLOSURE Compounds are described of the formula Image (I) wherein R1 and R4 independently represent a C1-4 alkyl group; R2 and R3 independently represent a C1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom; R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by a C1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.

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