Derivatives of 4-(trifluoromethyl)-phenol and...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 37/00 (2006.01) C07C 39/24 (2006.01) C07C 45/00 (2006.01) C07C 47/565 (2006.01) C07C 51/15 (2006.01) C07C 65/05 (2006.01) C07D 309/12 (2006.01) C07F 5/02 (2006.01) C07F 7/08 (2006.01)

Patent

CA 2418749

The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2- tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that a compound of formula (2) 4-(trifluoromethylphenyl)-2- (tetrahydropyranyl) ether is reacted with an electrophile E-X or a combination of electrophiles E-X and E-Y in the presence of a base, X and Y having the meanings given in the description.

L'invention concerne un procédé de production de dévirés du 4-(trifluorométhyl)-phénol et de l'éther 4-(2-trifluorométhyl)-phényl)-2-tétrahydropyranyl) substitués en 2 et 2,5 ainsi que de nouveaux dérivés. Le procédé est caractérisé en ce que l'on fait réagir, en présence d'une base, le composé de la formule éther de (2) 4-(trifluorométhylphényl)-2-(tétrahydropyranyl) avec un électrophile E-X ou une combinaison d'électrophiles E-X et E-Y, X et Y ayant la signification donnée dans la description.

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