Derivatives of 5-carboxyalkyl-2-iminobarbituric and...

Details Derivatives of 5-carboxyalkyl-2-iminobarbituric and... Derivatives of 5-carboxyalkyl-2-iminobarbituric and...

C - Chemistry, Metallurgy

07

D

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C07D 239/54 (2006.01) C07D 239/545 (2006.01) C07D 239/62 (2006.01)

Patent

CA 1051894

ABSTRACT OF THE DISCLOSURE: Derivatives of 5-carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids, having the general formula: Image (I) wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group containing 1 to 7 carbon atoms, R2 represents hydrogen or a straight or branched chain alkyl group containing 1 to 5 carbon atoms, R3 represents hydrogen, a straight or branched chain alkyl group containing 1 to 5 carbon atoms, or an aryl group, R4 represents an imino group or a sulphur atom, and n is 0 or an integer ranging from 1 to 6; and their phar- maceutically acceptable salts. These compounds are therapeu- tically useful in the treatment of animals with transplantable tumours.

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