Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines...

Details Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines... Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines...

A - Human Necessities

61

K

167/222

A61K 31/505 (2006.01)

Patent

CA 2005196

72222-130 ABSTRACT This invention relates to the use of certain derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines of the formula Image and the pharmaceutically-acceptable salts thereof, wherein R1 is H or CH3; R2 is CH3; R3 is (C3-C15) straight chain alkyl or (C7-C20)phenylalkyl which may be substituted in the phenyl by one or two fluoro or chloro substituents; and R4 is H or CH3 to inhibit interleukin-1 production in a mammal. This invention also relates to the use of such compounds for treating interleukin-1 mediated disorders and dysfunctions such as bone and connective tissue metabolism disorders and immune dysfunction in a mammal. The invention further relates pharmaceutical compositions adapted for such use.

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