Derivatives of 5-pentylamino-5-oxopentanoic and 4-...

Details Derivatives of 5-pentylamino-5-oxopentanoic and 4-... Derivatives of 5-pentylamino-5-oxopentanoic and 4-...

C - Chemistry, Metallurgy

07

C

167/208, 260/289

C07C 233/83 (2006.01) C07D 209/42 (2006.01) C07D 215/48 (2006.01) C07D 307/84 (2006.01) C07D 307/85 (2006.01) C07D 333/70 (2006.01)

Patent

CA 1292235

ABSTRACT OF THE DISCLOSURE New original derivatives are described of 5-pentylamino -5-oxopentanoic and 4-pentylamino-4-oxobutanoic acids having the formula: Image in which n is 1 or 2, R1 is selected from the groups 2 naphthyl, 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl, and R2 is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl, 3-methoxypropyl or 3 ethoxypropyl. The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system, such as colitis, biliary diskinesia, pancreatitis or in the treatment of disorders of the central nervous system imputable to deficiencies in the physiological neuron levels of cholecystokinin or other related bioactive polypeptides.

553811

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