Derivatives of 6-aminooctahydroindolizinetriol

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

IPC codes

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Type

Patent

Patent number

CA 2082820

Description

Amide and ester derivatives of 5-amino-octahydro- 1,7,8-indolizinetriol are described herein. The compounds have the general formula: (see formula I) wherein R is C1-10 alkanoyl; and R' and R" and R''' are independently hydrogen, C1-10 alkanoyl or benzoyl. The compounds are prepared from castanospermine by replacing the appropriate hydroxy function with an amino function while protecting the other hydroxy groups in the meantime. The compounds are useful as hexosaminidase inhibitors.

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