Derivatives of 7-alkynyl-1,8-naphthyridones, preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/02 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 403/02 (2006.01) C07D 471/02 (2006.01)

Patent

CA 2690349

The invention relates to compounds having formula (I), in which: R1 and R2 represent, independently of each other, a hydrogen atom, an alkyl group at C1-C7, optionally substituted by one or more alkoxy groups; R3 represents an alkyl group at C1-C7; R4 represents a hydrogen atom, an alkyl group at C1-C4; Y represents an alkoxy group at C1-C4, a group -NRR', -O(CH2)n-C(O)- NRR', wherein R and R' are as defined below and n is an integer equal to 1 or 2; R" represents an alkyl group at C1-C4; and R and R' represent, independently of each other, a hydrogen atom, a -CO-alkyl group at C1-C4 or a -COO" group, wherein R" is as defined above. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

L'invention concerne des composés répondant à la formule (I) : dans laquelle : R1 et R2 représentent indépendamment l'un de l'autre: un atome d'hydrogène, un groupe alkyle en C1-C7 éventuellement substitué par un ou plusieurs groupes alcoxy, R3 représente un groupe alkyle en C1-C7; R4 représente un atome d'hydrogène, un groupe alkyle en C1-C4; Y représente un groupe alcoxy en C1-C4, un groupe -NRR', -O(CH2)n-C(O)- NRR' où R et R' sont tels que définis ci-dessous et n est un nombre entier égal à 1 ou 2; R" représente un groupe alkyle en C1-C4; et R et R' représentent indépendamment l'un de l'autre un atome d'hydrogène, un groupe -CO-alkyle en C1-C4 ou un groupe -COOR", où R" tel que définis ci- dessus. Procédé de préparation et application en thérapeutique.

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