Derivatives of 9-chloroprednisolone

Details Derivatives of 9-chloroprednisolone Derivatives of 9-chloroprednisolone

C - Chemistry, Metallurgy

07

J

260/73, 260/86

C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 1100943

ABSTRACT OF THE DISCLOSURE New derivatives of 9-chloroprednisolone of the formula (I) , Image in which R1 represents an alkanoyl group containing 1 to 8 carbon atoms or a benzoyl group and X represents a fluorine atom, a chlorine atom, a hydroxyl group, an alkanoyloxy group containing 1 to 8 carbon atoms or a benzoyloxy group which are systemically almost inactive, but that in topical use they surprisingly have a strong anti-inflammatory activity, which generally exceeds that of the most active commercial corticoids.

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