Derivatives of 9-fluoroprednisolone

Details Derivatives of 9-fluoroprednisolone Derivatives of 9-fluoroprednisolone

C - Chemistry, Metallurgy

07

J

260/73, 260/86

C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 21/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1104124

ABSTRACT OF THE DISCLOSURE Derivatives of 9-fluoroprednisolone which hav? only weak systemic action but when administered topically have a strong anti-inflammatory action. The compounds have the formula Image wherein R1 represents a group of the general formula RCO- in which R represents a hydrogen atom or an alkyl group or a cyclo- alkyl or cycloalkylalkyl group or an alkyl-substituted cycloalkyl or cycloalkylalkyl group, and R1 has from 1 to 8 carbon atoms, or in which R represents an aryl or aralkyl group or an alkyl- substituted aryl or aralkyl group, and R1 has up to 9 carbon atoms, and X represents a fluorine or chlorine atom or a group of the general formula R'COO- which has from 3 to 8 carbon atoms and in which R' represents an alkyl group or a cycloalkyl or cycloalkylalkyl group or an alkyl-substituted cycloalkyl or cycloalkylalkyl group.

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