C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.08
C07K 7/64 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1216580
Abstract of the Invention This invention relates to A-21978C cyclic peptide derivatives of the formula Image in which R is hydrogen, a specified aminoacyl or N- alkanoylaminoacyl group, 8-methyldecanoyl, 10-methyl- dodecanoyl, 10-methylundecanoyl, the specific C10- alkanoyl group of A-21978C0 or the specific C12- alkanoyl groups of A-21978C factors C4 and C5 or an amino-protecting group; and R1 is hydrogen, an amino- protecting group, or a specified aminoacyl or N- alkanoylaminoacyl group; provided that, when R is other than aminoacyl or N-alkanoylaminoacyl, R1 must be aminoacyl or N-alkanoylaminoacyl; and, when R1 is an amino-protecting group, R must be aminoacyl or N- alkanoylaminoacyl; and the pharmaceutically-acceptable salts thereof. This invention also relates to the production of these useful antibiotics and intermediates to useful antibiotics. This process includes acylating the appropriately protected A-21978C nucleus with the desired acylating agent or an activated derivative thereof, and optionally, if desired, removing any protecting group present in the product of the reaction.
428103
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Derivatives of a-21978c cyclic peptides and their production does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of a-21978c cyclic peptides and their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of a-21978c cyclic peptides and their production will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1321130