Derivatives of aminosulfonic acids, utilization of the same...

C - Chemistry – Metallurgy – 07 – C

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C07C 309/69 (2006.01) C07C 309/21 (2006.01) C07C 309/83 (2006.01) C07C 311/47 (2006.01) C07D 207/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2189896

Derivatives of gamma-amino-alpha,beta-unsaturated sulphonic acids of formula (I), where: R is chosen among hydrogen; fragments corresponding to side-chains of natural amino acids, substituted or unsubstituted; linear, branched or cyclic alkyl chains; arylalkyl chains; aryl or heteroaromatic groups; Y indicates hydrogen, including possible saline forms of the corresponding amine; or any protective group commonly utilised for the protection of the amine group; X indicates Cl, OH, OCH2CH3, OCH3, ONBu4, NHCH2Ph; process for the preparation of the same and their utilisation in the synthesis of pseudopeptides characterised by the presence of at least one sulphonamide-type bond conjugated to a double bond.

Dérivés d'acides sulfoniques gamma-amino-alpha,bêta-insaturés répondant à la formule (I), dans laquelle R est choisi parmi hydrogène; des fragments correspondant aux chaînes latérales d'acides aminés naturels éventuellement substitués; des chaînes alkyle linéaires, ramifiées ou cycliques; des chaînes arylalkyle; des groupes aryle ou hétéroaromatiques; Y représente hydrogène, et notamment les éventuelles formes salines de l'amine correspondante; ou tout groupe protecteur habituellement utilisé pour protégér le groupe aminé; et X représente Cl, OH, OCH¿2?CH¿3?, OCH¿3?, ONBu¿4?, NHCH¿2?Ph; leur procédé de préparation et leur application à la synthèse de pseudopeptides, caractérisés par la présence d'au moins une liaison de type sulfonamide conjuguée à une liaison double.

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