Derivatives of an aminoketone

Details Derivatives of an aminoketone Derivatives of an aminoketone

C - Chemistry, Metallurgy

07

C

260/576, 260/325

C07C 225/16 (2006.01) C07C 45/29 (2006.01) C07C 45/46 (2006.01) C07C 49/76 (2006.01) C07C 49/782 (2006.01) C07C 49/794 (2006.01) C07C 49/798 (2006.01) C07C 49/80 (2006.01) C07C 49/807 (2006.01) C07C 49/825 (2006.01) C07C 49/83 (2006.01) C07C 49/84 (2006.01) C07D 295/108 (2006.01) C07D 295/112 (2006.01)

Patent

CA 1276155

ABSTRACT: A new aminoketone derivative having a central muscle relaxant activity which is represented by the following general formula: Image wherein R1 and Image are the groups defined as I, II or III below, one of R2 and R3 is a hydrogen atom and the other is a lower alkyl group; n is 0 when R1 is I or II, and it is 0 or 1 when R1 is III: I: R1 is a group selected from the groups ? to ? mentioned below and Image ? a group of the formula Image (wherein R4 is a trihalogenomethyl group), ? a group of the formula Image (wherein R5 is a fluorine atom, a bromine atom, a lower alkoxyl group, a lower alkyl group, hydroxyl group, CH2=CH-, a phenyl group or Image , ? a group of the formula Image (wherein R6 is a halogen atom, a lower alkyl group, Image , CH2=CH- or phenyl group), ? a group of the formula Image (wherein both R7 and R8 each are halogen atoms, lower alkyl groups, lower alkoxyl groups or hydrogen atoms), ? a group of the formula Image (wherein R9 and R10 each are halogen atoms, lower alkyl groups or lower alkoxyl group, and R10 is a substituent at the position 4 or 5 of the phenyl ring), ? a group of the formula Image (Wherein R9 is a lower alkoxyl group, a lower alkyl group or a halogen atom; R11 is a substituent at the position 2 or 3 of the phenyl ring, and is a lower alkyl ? a group of the formula Image (wherein R15 and R16 each are lower alkyl groups or lower alkoxyl groups and R19 is a lower alkyl group, provided that R16 is a substituent at the position 3 or 4): III: R1 is a group selected from the groups ?, ?, ? or ? mentioned below and Image is a group of the formula Image ? a group of the formula Image (wherein R20 is a hydrogen atom, a haIogen atom, Image a lower alkyl group or a lower alkoxyl group), a group of the formula Image (wherein R21 is a halogen atom, a lower alkyl group or a lower alkoxyl group), ? a group of the formula Image (wherein R22 is a lower alkoxyl group), and ? a group of the formula Image (wherein R23 is a halogen atom or a lower alkyl group, R24 and R25 each are lower alkyl groups, and R26 is a lower alkyl group or a lower alkoxyl group), its pharmaceutically acceptable salt and a process for manufacturing thereof.

506340

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