Derivatives of arginine vasopressin antagonists

Details Derivatives of arginine vasopressin antagonists Derivatives of arginine vasopressin antagonists

C - Chemistry, Metallurgy

07

K

530/7.06, 530/7.

C07K 7/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1245634

Abstract Compounds acting as antagonists of the antidiuretic of argin- ine vasopressin are those of the formula Image Wherein n is 4 or 5; X is D-Tyr(R), D-Phe, D-Val, D-Leu, D-He, D-Nvn, D-Nle, D-Cha, D-Abu, D-Thr, D-Met, D-Asn or D-Gln; Y is He, Thr, Gln Ala, Lys, Cha, Nva, Nle, Orn, Ser, Asn, Met, Abu or Leu; W is (i)- or L-)Pro, Hy-Pro or .DELTA.3-Pro; Z is (i)- or L-)Arg, Orn or Lys and R is methyl ethyl, propyl or butyl.

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