Derivatives of aryl-quinazoline/aryl-2-amino-phenyl...

Details Derivatives of aryl-quinazoline/aryl-2-amino-phenyl... Derivatives of aryl-quinazoline/aryl-2-amino-phenyl...

C - Chemistry, Metallurgy

07

D

C07D 239/78 (2006.01) A61K 31/136 (2006.01) A61K 31/517 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) C07C 221/00 (2006.01) C07C 225/22 (2006.01)

Patent

CA 2509151

A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.

La présente invention concerne un composé de la formule (1) dans laquelle R1, R2, R3 et Y sont tels que définis dans la description, ou un ester pharmaceutiquement acceptable et clivable, ou un sel d'addition acide de ce dernier, lequel composé est utilisé pour stimuler la libération de l'hormone parathyroïde, p.ex. pour prévenir ou traiter les états osseux qui sont associés à une déplétion ou une résorption calcique augmentée ou dans lesquels il est souhaitable de stimuler la formation osseuse et la fixation osseuse du calcium.

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