C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61P 43/00 (2006.01) C07H 3/02 (2006.01)
Patent
CA 2580235
Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.
L'invention concerne des dérivés d'acide hydroxamique substitués par arylsulfonamido de formule (I) présentant une bonne solubilité dans l'eau et un effet inhibiteur sur les métalloprotéinases matricielles. Ces composés sont utiles pour la préparation de compositions pharmaceutiques, servant au traitement de maladies associées à une activité pathologique et/ou à une surexpression de métalloprotéinases, et de préparations cosmétiques à effet anti-âge en particulier pour les cheveux et la peau.
Bertini Ivano
Fragai Marco
Lo Conte Mauro
Luchinat Claudio
Nativi Cristina
Abiogen Pharma S.p.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Protera S.r.l.
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