Derivatives of asimadoline with covalently bonded acids

Details Derivatives of asimadoline with covalently bonded acids Derivatives of asimadoline with covalently bonded acids

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2510167

The invention relates to derivatives of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3- hydroxypyrrolidine-1-yl)-ethyl]-2,2-diphenyl acetamide comprising covalently bonded acids and to the salts, solvates and prodrugs of said derivatives. The invention also relates to the use of the derivatives as medicaments, to their use for producing a medicament and for producing a pharmaceutical composition, to a method for producing said pharmaceutical compositions, to pharmaceutical compositions obtained by said method and to a method for treating diseases, comprising the administration of the aforementioned pharmaceutical composition.

L'invention concerne des dérivés de N-méthyle-N-[(1S)-1-phényle-2-((3S)-3-hydroxypyrrolidine-1-yl)-éthyle]-2,2-diphényle-acétamide comportant des acides liés par covalence et les sels, les solvates et les promédicaments de ces dérivés. La présente invention porte également sur ces dérivés employés comme médicaments, sur leur utilisation pour préparer un médicament, sur leur utilisation pour préparer une composition pharmaceutique, sur un procédé pour réaliser ces préparations pharmaceutiques, sur des préparations pharmaceutiques obtenues par ce procédé, ainsi que sur le traitement de maladies comprenant l'administration de ladite composition pharmaceutique.

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