Derivatives of aspartic acid and glutamic acid having...

Details Derivatives of aspartic acid and glutamic acid having... Derivatives of aspartic acid and glutamic acid having...

C - Chemistry, Metallurgy

07

C

C07C 311/00 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/41 (2006.01) A61K 31/47 (2006.01) C07C 311/06 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07D 217/06 (2006.01) C07D 257/04 (2006.01) C07D 307/66 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2087193

2087193 9200958 PCTABS00010 Cholecystokinin antagonists are provided having formula (I) wherein Ar is (a), (b), (c), (d), (e), (f) or (g) (wherein the aromatic moiety may be substituted or unsubstituted), or (h); R1 is H, C1 to C6 alkyl, C1 to C6 alkenyl, cycloalkyl, -(CH2)qaryl, -(CH2)q(substituted aryl) or -(CH2)qheterocyclic, wherein q is 0 to 4; R2 is H, methyl or ethyl; T is carboxyl, -CONR5R6 (wherein R5 and R6 are independently H or C1 to C4 alkyl) or tetrazolyl; n is 0 to 3, and Q is (i) or (j) wherein X is C1 to C4 alkyl, C1 to C4 alkoxy, C1 to C4 thioalkoxy, carboxy, C1 to C4 carboalkoxy, nitro, trihalomethyl, hydroxy, -NR7R8 (wherein R7 and R8 are independently H or C1 to C4 alkyl), C1 to C4 alkylaryl, C1 to C4 alkyl(substituted aryl) or halo; m is 1 to 3; p is 0 to 3; and R3 is H, C1 to C5 alkyl or -(CH2)rR4 wherein r is 0 to 4 and R4 is aryl or substituted aryl; and pharmaceutically acceptable salts thereof.

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