Derivatives of benzimidazoles

Details Derivatives of benzimidazoles Derivatives of benzimidazoles

C - Chemistry, Metallurgy

07

D

260/314.3

C07D 235/32 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1117538

GS90/95 ABSTRACT Derivatives of Benzimidazoles Benzimidazoles are provided having the structure Image wherein R is lower alkyl or phenyl-lower alkyl and A is Image wherein R1 is lower alkyl, R2 is hydrogen or lower alkyl, or R1 and R2 may be taken together with the carbons to which they are attached to form a cycloalkenyl ring, R3 is hydrogen or lower alkyl, and y is 0 or 1; Image herein R4 and R5 are the same or different and are hydrogen or lower alkyl, R6 is lower alkyl or phenyl, and R7 and R8 are the same or different and are chlorine, bromine, fluorine or iodine, m is 0 to 3, n is 0 to 3, and m + n is ? 5; or GS90/95 Image wherein R9, R10 and R11 may be the same or different and may be lower alkyl or lower alkoxy, z is 0, 1 or 2 and p is 1 to 5, with the proviso that when A is Image R is lower alkyl. The benzimidazoles have anthelmintic activity and are useful in the treatment and/or preven- tion of helminthiasis.

316928

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